Probiotic-Derived Factors: Probiotaceuticals?
نویسندگان
چکیده
منابع مشابه
Probiotic safety and risk factors.
Probiotics are defined by the Food and Agriculture Organization of the United States as “live microorganisms which, when administered in adequate amounts, confer a health benefit on the host.”1 They are considered nutritional supplements and, as such, are classified as Generally Regarded as Safe (GRAS). Organisms of the probiotic groups are added to all sorts of foods, particularly yogurts, but...
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Lactobacillus reuteri (L. reuteri) is a probiotic that inhibits the severity of enteric infections and modulates the immune system. Human-derived L. reuteri strains DSM17938, ATCC PTA4659, ATCC PTA 5289, and ATCC PTA 6475 have demonstrated strain-specific immunomodulation in cultured monocytoid cells, but information about how these strains affect inflammation in intestinal epithelium is limite...
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The endothelium not only mediates relaxation but is a source of contracting factors. Endothelium-dependent contractions are elicited by physical and chemical stimuli (i.e., hypoxia, pressure, and stretch) and autacoids, local and circulating hormones. The mechanism of endothelium-dependent contractions to hypoxia involves withdrawal of nitric oxide. The endothelial cyclooxygenase pathway can pr...
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Inflammatory bowel disease frequently causes intestinal obstruction because of extensive fibrosis. This study investigated whether polyphosphate (poly P), an active molecule derived from Lactobacillus brevis, could improve the fibrosis in a model of chronic colitis. In this study, dextran sodium sulfate (DSS)-induced chronic colitis models and trinitrobenzene sulfonic acid (TNBS)-induced coliti...
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Probiotics exhibit beneficial functions for host homeostasis maintenance. We herein investigated the mechanism by which Lactobacillus brevis-derived poly P exhibited a beneficial function. Immunostaining indicated that poly P was captured in the plasma membrane via integrin β1 in Caco2/bbe cells. The uptake of poly P was reduced by the inhibition of integrin β1 as well as caveolin-1, a major co...
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ژورنال
عنوان ژورنال: The Journal of Nutrition
سال: 2009
ISSN: 0022-3166,1541-6100
DOI: 10.3945/jn.109.118844